“A multicenter team led by Case Western Reserve has demonstrated that brief exposure to a targeted therapy can tell doctors which HER2-negative patients will respond — and which should switch to another kind of treatment.
If confirmed in clinical trials, the discovery would provide physicians invaluable information regarding the effectiveness of bevacizumab, known commercially as Avastin. Such early results would spare patients weeks of the medication’s sometimes severe side effects, and also allow them to pursue options with greater chances for success. The findings appear in this month’s International Journal of Cancer.
“What all this means is that we have identified a signature that tells us which patients are likely to respond to bevacizumab and chemotherapy,” said Principal Investigator and senior author Lyndsay Harris, MD, Professor of Medicine at Case Western Reserve, “and we can identify those patients within 15 days of the very first dose they receive.”
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