Scientists at the University of Toledo Health Science Campus (UT) and Van Andel Research Institute (VARI) have discovered an innovative way that may stop the spread of the most lethal and aggressive brain cancer glioblastoma multiforme (GBM). In laboratory studies, scientists demonstrated that activating a specific family of proteins halted cancer cell migration into healthy tissue.
GBM is the most common brain tumor in adults; in 2010, there were 22,000 cases in the U.S. People with GBM often live fewer than than 15 months following diagnosis because, despite surgery, radiation and chemotherapy, individual cancer cells escape and invade healthy surrounding tissue, making additional treatment attempts increasingly difficult.
“New therapies for GBM are desperately needed,” said UT Assistant Professor Kathryn Eisenmann, Ph.D., corresponding author on the study. “We hope our latest finding will lead to a novel and effective treatment for this extremely aggressive cancer.”
The study, published online Sept. 9 by the American Society of Cell Biology in the journal Molecular Biology of the Cell, expands upon an earlier discovery by VARI Professor Arthur Alberts, Ph.D., of a bioactive peptide called DAD and small molecules called intramimics.
Full article here