New discoveries can let tp better treatment. Lets hope this keeps moving in the right direction. “A group of researchers at Osaka University in cooperation with the Japan Synchrotron Radiation Research Institute (JASRI), succeeded in elucidating the secondary structure of Lewy bodies in the brain of Parkinson’s disease patients for the first time with synchrotron Fourier transform infrared micro-spectroscopy (FTIRM).
Lewy bodies had been considered to be a key element of pathogenesis for Parkinson’s disease. Although structural analysis for Lewy bodies with an electron microscope had been performed, it had no secondary structural information of proteins, which is important for the development of drugs.
In recent years, many researchers have focused on new treatment to inhibit the formation of abnormal protein aggregates, which can delay the onset and progression of Parkinson’s disease. The results and methods of this research may provide important clues to the development of epoch-making treatment for Parkinson’s disease.
Parkinson’s disease is the most common progressive neurodegenerative disorder after Alzheimer’s disease, and there is no basic treatment to control the development of the disease. It had been known for quite some time that Lewy bodies, abnormal protein aggregates, are formed in the brain of Parkinson’s disease patients, and it is thought that Lewy bodies play an important role in the onset of the disease. However, the structural analysis of Lewy bodies has made no progress other than observation with an electronic microscope in the last 20 years. Information on proteins required for developing treatment drugs has been unavailable from electron microscopic observation.”
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