Genetic traits have a lot to do with your health as you age. “
Such hemorrhages in brain tissue — microbleeds — leave small points of damage throughout the brain and contribute to memory loss.
The study led by USC Davis School of Gerontology scientists reveals that the gene variant, ApoE4, has different effects on men and women diagnosed with mild cognitive impairment or Alzheimer’s disease.
The research further underscores the significance of ApoE4 (apolipoprotein E 4) in Alzheimer’s, and it builds upon prior studies that indicate the disease has sex-based differences that may affect treatment approaches.
“It’s important to study sex-based differences in Alzheimer’s because women live longer than men, and, as this study shows, the disease can affect them differently,” said corresponding author Caleb Finch, University Professor in the USC Davis School of Gerontology and Dornsife College of Letters, Arts, and Sciences.
The finding is especially striking since prior research indicated that Alzheimer’s disease was more troublesome for women. Women with ApoE4 are almost twice more likely than men to be diagnosed with the disease. Also, women suffer worse memory loss than men for a given load of plaques and tangles of proteins — the classic Alzheimer’s disease markers.”
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